Orphan endogenous lipids and orphan GPCRs: A good match
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چکیده
منابع مشابه
Orphan GPCRs and Neuromodulation
Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators. These discoveries have had profound impact on our understanding of brain function. Here, I present an overview of how some of ...
متن کاملEditorial: Orphan GPCRs As Emerging Drug Targets
G protein coupled-receptors (GPCRs) have been proven to be the most successful class of druggable targets in the human genome. In fact, 30–50% of marketed drugs are estimated to exert their clinical effects via GPCRs. Furthermore, the pace of GPCR-targeted new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) in the recent years still remains to a level near its hi...
متن کاملAdvancements in therapeutically targeting orphan GPCRs
G-protein coupled receptors (GPCRs) are popular biological targets for drug discovery and development. To date there are more than 140 orphan GPCRs, i.e., receptors whose endogenous ligands are unknown. Traditionally orphan GPCRs have been difficult to study and the development of therapeutic compounds targeting these receptors has been extremely slow although these GPCRs are considered importa...
متن کاملThe therapeutic potential of orphan GPCRs, GPR35 and GPR55
The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family of signal transducers, comprised of ∼1000 members. Considering their prevalence and functional importance, it's not surprising that ∼60% of drugs target GPCRs. Regardless, there exists a subset of the GPCR superfamily that is largely uncharacterized and poorly understood; specifically, more than 140 GPC...
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ژورنال
عنوان ژورنال: Prostaglandins & Other Lipid Mediators
سال: 2009
ISSN: 1098-8823
DOI: 10.1016/j.prostaglandins.2009.04.006